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A plate of Southern Chicken Spaghetti topped with fresh herbs and melted cheese, served alongside a side of crispy Southern-style vegetables.

The Ultimate Zesty Southern Chicken Spaghetti: A Comfort Food Dream!

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Indulge in the ultimate comfort food with our Zesty Southern Chicken Spaghetti. This flavorful casserole combines tender shredded chicken, perfectly cooked pasta, zesty seasonings, and gooey cheeses for a hearty, spicy dish that’s easy to prepare and perfect for any weeknight dinner or weekend gathering. Packed with vibrant flavors and a hint of heat, this Southern-style chicken spaghetti will become your new favorite go-to meal.

  • Total Time: 45 minutes
  • Yield: 6 servings

Ingredients

Scale
  • 3 cups cooked chicken, shredded
  • 12 oz spaghetti pasta
  • 1 can diced tomatoes with green chilies (10 oz)
  • 1 cup bell peppers, chopped
  • 1 onion, diced
  • 3 cloves garlic, minced
  • 1 cup shredded cheddar cheese
  • 1 cup shredded Monterey Jack cheese
  • 1 cup sour cream
  • 1/2 cup chicken broth
  • 2 tbsp olive oil
  • 2 tsp Cajun seasoning
  • 1 tsp smoked paprika
  • 1/2 tsp crushed red pepper flakes
  • Salt and black pepper to taste

Instructions

  1. Cook the spaghetti in boiling salted water according to package instructions until al dente. Drain and set aside.
  2. Heat 1 tablespoon of olive oil in a large skillet over medium heat. Add diced onions and bell peppers, sauté until soft. Stir in minced garlic and cook for 1 minute. Add shredded cooked chicken, season with Cajun seasoning, smoked paprika, red pepper flakes, salt, and pepper. Cook for 2-3 minutes to combine flavors.
  3. Pour in chicken broth and diced tomatoes with green chilies into the skillet. Bring to a simmer, then stir in sour cream and cook for 5 minutes. Mix in the cooked pasta, tossing to coat evenly.
  4. Preheat oven to 375°F (190°C). Transfer pasta mixture into a greased baking dish. Top with cheddar and Monterey Jack cheeses.
  5. Bake uncovered for 20-25 minutes until cheese bubbles and turns golden. Broil for an additional 2 minutes if desired, watching carefully.

Notes

  • Use cooked, shredded chicken for best results.
  • Adjust the red pepper flakes to control spice level.
  • For a creamier consistency, add extra sour cream or cheese.
  • This dish can be made ahead and refrigerated for up to 3 days.
  • Author: Emma Bloomfield
  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Category: Dinner
  • Method: Baking, Sautéing
  • Cuisine: Southern
  • Diet: Contains Meat

Nutrition

  • Serving Size: 1 cup
  • Calories: 520 Kcal
  • Sugar: 8g
  • Sodium: 890mg
  • Fat: 25g
  • Saturated Fat: 12g
  • Unsaturated Fat: 10g
  • Trans Fat: 0g
  • Carbohydrates: 55g
  • Fiber: 4g
  • Protein: 35g
  • Cholesterol: 125mg